Pokémon
Booster Box Answer
Usually only if you want the opening experience and would be happy with several different hits. If one chase card is doing all the work, a booster box is often the expensive way to miss.
The fastest check is simple: what is the chance you still miss after 36 packs? HiddenSnags puts that answer directly in the calculator.
What to do next: pick the card you care about and check the 36-pack miss chance in the calculator.
Two fast reality checks
If you would regret missing after a full box, the box probably was not worth it for your real goal.
If the box cost is already close to the card you want, you usually need early luck for the sealed plan to hold up.
Calculator shortcut
Run the card through the calculator and focus on the chance you still miss after 36 packs and the point where packs usually become a bad deal.
If both look rough, buying the card is usually the smarter move.
Best next step
Check the exact card you care about before you treat a full box as the plan.
Check a card in the calculator